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21-dehydro-17-deoxy dexamethasone

21-dehydro-17-deoxy dexamethasone

Catalogue No.: VL273020
CAS No.: N/A

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Name: 21-dehydro-17-deoxy dexamethasone
Catalogue No. VL273020
Molecular Formula C₂₂H₂₉FO₆
Molecular Weight 408.46
Status In-stock
IUPAC Name (11β,16α)-9-Fluoro-11,17-dihydroxy-16-methyl-3,20-dioxopregna-1,4-dien-21-al Hydrate
Description 21-dehydro-17-deoxy dexamethasone or (11β,16α)-9-Fluoro-11,17-dihydroxy-16-methyl-3,20-dioxopregna-1,4-dien-21-al Hydrate is a degradation product of Dexamethasone which is a drug of choice for the treatment of Myeloma. Dexamethasone (DEX) itself was effective in about a quarter of myeloma patients having the resistant disease.
References ‌“ISOLATION, IDENTIFICATION, and CHARACTERIZATION of 17-OXO DEXAMETHASONE, an OXIDATIVE DEGRADATION IMPURITY of DEXAMETHASONE USING FLASH CHROMATOGRAPHY and NMR/HRMS/IR.” Journal of Liquid Chromatography & Related Technologies, 2014,www.tandfonline.com/doi/abs/10.1080/10826076.2013.836712.‌Alexanian, R., et al. “Primary Dexamethasone Treatment of Multiple Myeloma.” Blood, vol. 80, no. 4, Aug. 1992, pp. 887–90,https://doi.org/10.1182/blood.v80.4.887.887.‌

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