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Abacavir EP Impurity A

Abacavir EP Impurity A

Catalogue No.: VL760013
CAS No.: 136470-79-6

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Name: Abacavir EP Impurity A
Catalogue No. VL760013
CAS No. 136470-79-6
Molecular Formula C14H18N6O
Molecular Weight 286.33
Status In-stock
IUPAC Name ((1R,4S)-4-(2-amino-6-(cyclopropylamino)-9H-purin-9-yl)cyclopent-2-en-1-yl)methanol
Appearance Off-White to Pale Yellow Solid
Description Abacavir EP Impurity A (CAS No: 136470-79-6) is a degradation product of Abacavir that is a nucleoside reverse transcriptase inhibitor that acts by inhibiting HIV reverse transcriptase by competing with the endogenous substrate dGTP and thus, is utilized in the treatment of HIV infection.
References Kurmi, Moolchand, et al. “Stability Behaviour of Antiretroviral Drugs and Their Combinations. 5: Characterization of Novel Degradation Products of Abacavir Sulfate by Mass and Nuclear Magnetic Resonance Spectrometry.” Journal of Pharmaceutical and Biomedical Analysis, vol. 134, Feb. 2017, pp. 372–84, https://doi.org/10.1016/j.jpba.2016.10.019. ‌Vukkum, Pallavi. “Stress Degradation Behavior of Abacavir Sulfate and Development of a Suitable Stability-Indicating UHPLC Method for the Determination

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