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Abacavir EP Impurity D

Abacavir EP Impurity D

Catalogue No.: VL760005
CAS No.: 783292-37-5 (free base), 267668-71-3 (Salt)

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Name: Abacavir EP Impurity D
Catalogue No. VL760005
CAS No. 783292-37-5 (free base), 267668-71-3 (Salt)
Molecular Formula C14H20Cl2N6O
Molecular Weight 359.25
Status In-stock
IUPAC Name [(1R,4R)-4-[2-Amino-6-(cyclopropylamino)-9H-purin-9-yl]cyclopent-2-enyl]methanol dihydrochloride
Synonyms trans-Abacavir Dihydrochloride
Description Abacavir EP Impurity D [CAS No: 783292-37-5 (free base), 267668-71-3 (Salt)] or Abacavir Related Compound 8 / trans-Abacavir Dihydrochloride is formed by degradation of Abacavir. Abacavir is an antiretroviral drug that acts by decreasing viral load and increased CD4+ cell count in HIV-infected patients.
References Foster RH, Faulds D. Abacavir. Drugs. 1998 May;55(5):729-36; discussion 737-8. DOI: 10.2165/00003495-199855050-00018. PMID: 9585869. Kurmi, Moolchand, et al. “Stability Behaviour of Antiretroviral Drugs and Their Combinations. 5: Characterization of Novel Degradation Products of Abacavir Sulfate by Mass and Nuclear Magnetic Resonance Spectrometry.” Journal of Pharmaceutical and Biomedical Analysis, vol. 134, Feb. 2017, pp. 372–84, https://doi.org/10.1016/j.jpba.2016.10.019.

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