| Name: | Abacavir Related Compound B |
| Catalogue No. | VL760025 |
| CAS No. | 141271-12-7 |
| Molecular Formula | C10H14ClN5O |
| Molecular Weight | 255.7 |
| Status | Under Development |
| IUPAC Name | (4-((2,5-diamino-6-chloropyrimidin-4-yl)amino)cyclopent-2-en-1-yl)methanol |
| Description | Abacavir Related Compound B (CAS No: 141271-12-7) is an impurity of Abacavir that is a carbocyclic 2′-deoxyguanosine nucleoside analog. The mechanism includes its conversion intracellularly to a 2′-deoxyguanosine nucleoside analog that competitively restrains HIV reverse transcriptase and eliminates proviral DNA chain extension. |
| References | Hervey, Pauline S., and Caroline M. Perry. “Abacavir.” Drugs, vol. 60, no. 2, Aug. 2000, pp. 447–79, https://doi.org/10.2165/00003495-200060020-00015. Jain, Mohit, et al. “A Simple and Sensitive Method for the Ultra Trace Determination of Potential Genotoxic Impurities in Abacavir Sulfate by LC-MS.” Chemical Methodologies, vol. 2, no. 4, Sami Publishing Company, Oct. 2018, pp. 315–23, https://doi.org/10.22034/chemm.2018.66185. |
