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Abacavir Related Compound B

Abacavir Related Compound B

Catalogue No.: VL760025
CAS No.: 141271-12-7

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Name: Abacavir Related Compound B
Catalogue No. VL760025
CAS No. 141271-12-7
Molecular Formula C10H14ClN5O
Molecular Weight 255.7
Status Under Development
IUPAC Name (4-((2,5-diamino-6-chloropyrimidin-4-yl)amino)cyclopent-2-en-1-yl)methanol
Description Abacavir Related Compound B (CAS No: 141271-12-7) is an impurity of Abacavir that is a carbocyclic 2′-deoxyguanosine nucleoside analog. The mechanism includes its conversion intracellularly to a 2′-deoxyguanosine nucleoside analog that competitively restrains HIV reverse transcriptase and eliminates proviral DNA chain extension.
References Hervey, Pauline S., and Caroline M. Perry. “Abacavir.” Drugs, vol. 60, no. 2, Aug. 2000, pp. 447–79, https://doi.org/10.2165/00003495-200060020-00015. ‌Jain, Mohit, et al. “A Simple and Sensitive Method for the Ultra Trace Determination of Potential Genotoxic Impurities in Abacavir Sulfate by LC-MS.” Chemical Methodologies, vol. 2, no. 4, Sami Publishing Company, Oct. 2018, pp. 315–23, https://doi.org/10.22034/chemm.2018.66185. ‌

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