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Afatinib Impurity B

Afatinib Impurity B

Catalogue No.: VL5510005
CAS No.: 314771-76-1

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Name: Afatinib Impurity B
Catalogue No. VL5510005
CAS No. 314771-76-1
Molecular Formula C18H16ClFN4O2
Molecular Weight 374.81
Status Under Development
IUPAC Name N4-(3-Chloro-4-fluorophenyl)-7-[[(3S)-tetrahydro-3-furanyl]oxy]-4,6-quinazolinediamine
Description Afatinib Impurity B (CAS No: 314771-76-1) is a degradation product of an anilinoquinazoline derivative afatinib that acts by irreversibly inhibiting tyrosine kinase receptors. It is utilized in the treatment of metastatic non-small lung cancer.
References Chavan, Balasaheb B., et al. “Isolation and Structural Characterization of Degradation Products of Afatinib Dimaleate by LC-Q-TOF/MS/MS and NMR: Cytotoxicity Evaluation of Afatinib and Isolated Degradation Products.” Journal of Pharmaceutical and Biomedical Analysis, vol. 166, Mar. 2019, pp. 139–46, https://doi.org/10.1016/j.jpba.2019.01.004.

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