| Name: | Afatinib Impurity B |
| Catalogue No. | VL5510005 |
| CAS No. | 314771-76-1 |
| Molecular Formula | C18H16ClFN4O2 |
| Molecular Weight | 374.81 |
| Status | Under Development |
| IUPAC Name | N4-(3-Chloro-4-fluorophenyl)-7-[[(3S)-tetrahydro-3-furanyl]oxy]-4,6-quinazolinediamine |
| Description | Afatinib Impurity B (CAS No: 314771-76-1) is a degradation product of an anilinoquinazoline derivative afatinib that acts by irreversibly inhibiting tyrosine kinase receptors. It is utilized in the treatment of metastatic non-small lung cancer. |
| References | Chavan, Balasaheb B., et al. “Isolation and Structural Characterization of Degradation Products of Afatinib Dimaleate by LC-Q-TOF/MS/MS and NMR: Cytotoxicity Evaluation of Afatinib and Isolated Degradation Products.” Journal of Pharmaceutical and Biomedical Analysis, vol. 166, Mar. 2019, pp. 139–46, https://doi.org/10.1016/j.jpba.2019.01.004. |
