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Afatinib Impurity C

Afatinib Impurity C

Catalogue No.: VL5510006
CAS No.: 945553-91-3

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Name: Afatinib Impurity C
Catalogue No. VL5510006
CAS No. 945553-91-3
Molecular Formula C24H25ClFN5O3
Molecular Weight 485.94
Status Under Development
IUPAC Name (2E)-N-[4-[(3-Chloro-4-fluorophenyl)amino]-7-[[(3R)-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-4-(dimethylamino)-2-butenamide
Description Afatinib Impurity C (CAS No: 945553-91-3) is formed by the degradation of an anilinoquinazoline derivative afatinib that is used to treat metastatic non-small lung cancer. It acts by irreversibly inhibiting tyrosine kinase receptors.
References Chavan, Balasaheb B., et al. “Isolation and Structural Characterization of Degradation Products of Afatinib Dimaleate by LC-Q-TOF/MS/MS and NMR: Cytotoxicity Evaluation of Afatinib and Isolated Degradation Products.” Journal of Pharmaceutical and Biomedical Analysis, vol. 166, Mar. 2019, pp. 139–46, https://doi.org/10.1016/j.jpba.2019.01.004.

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