| Name: | Afatinib Impurity C |
| Catalogue No. | VL5510006 |
| CAS No. | 945553-91-3 |
| Molecular Formula | C24H25ClFN5O3 |
| Molecular Weight | 485.94 |
| Status | Under Development |
| IUPAC Name | (2E)-N-[4-[(3-Chloro-4-fluorophenyl)amino]-7-[[(3R)-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-4-(dimethylamino)-2-butenamide |
| Description | Afatinib Impurity C (CAS No: 945553-91-3) is formed by the degradation of an anilinoquinazoline derivative afatinib that is used to treat metastatic non-small lung cancer. It acts by irreversibly inhibiting tyrosine kinase receptors. |
| References | Chavan, Balasaheb B., et al. “Isolation and Structural Characterization of Degradation Products of Afatinib Dimaleate by LC-Q-TOF/MS/MS and NMR: Cytotoxicity Evaluation of Afatinib and Isolated Degradation Products.” Journal of Pharmaceutical and Biomedical Analysis, vol. 166, Mar. 2019, pp. 139–46, https://doi.org/10.1016/j.jpba.2019.01.004. |
