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Afatinib Impurity G

Afatinib Impurity G

Catalogue No.: VL5510010
CAS No.: N/A

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Name: Afatinib Impurity G
Catalogue No. VL5510010
CAS No. N/A
Molecular Formula C24H25ClFN5O3
Molecular Weight 485.95
Status Under Development
IUPAC Name (S,Z)-N-(4-((4-chloro-3-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-4-(dimethylamino)but-2-enamide
Description Afatinib Impurity G is produced by the degradation of Afatinib that is an anilinoquinazoline derivative and irreversible tyrosine kinase receptor inhibitor used in the therapy of metastatic non-small cell lung cancer.
References Chavan, Balasaheb B., et al. “Isolation and Structural Characterization of Degradation Products of Afatinib Dimaleate by LC-Q-TOF/MS/MS and NMR: Cytotoxicity Evaluation of Afatinib and Isolated Degradation Products.” Journal of Pharmaceutical and Biomedical Analysis, vol. 166, Mar. 2019, pp. 139–46, https://doi.org/10.1016/j.jpba.2019.01.004.

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