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Afatinib Impurity H

Afatinib Impurity H

Catalogue No.: VL5510011
CAS No.: N/A

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Name: Afatinib Impurity H
Catalogue No. VL5510011
CAS No. N/A
Molecular Formula C22H20ClFN4O3
Molecular Weight 442.88
Status Under Development
IUPAC Name (S,E)-N-(4-((3-chloro-4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-enamide
Description Afatinib Impurity H is an intermediate formed during the degradation of Afatinib that selectively and irreversibly binds and inhibits the epidermal growth factor receptors which lead to the inhibition of tumour growth and angiogenesis in tumour cells.
References Chavan, Balasaheb B., et al. “Isolation and Structural Characterization of Degradation Products of Afatinib Dimaleate by LC-Q-TOF/MS/MS and NMR: Cytotoxicity Evaluation of Afatinib and Isolated Degradation Products.” Journal of Pharmaceutical and Biomedical Analysis, vol. 166, Mar. 2019, pp. 139–46, https://doi.org/10.1016/j.jpba.2019.01.004.

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