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Afatinib Impurity J

Afatinib Impurity J

Catalogue No.: VL5510013
CAS No.: 1456696-14-2

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Name: Afatinib Impurity J
Catalogue No. VL5510013
CAS No. 1456696-14-2
Molecular Formula C18H22N4O4
Molecular Weight 358.39
Status Under Development
IUPAC Name (S,E)-4-(dimethylamino)-N-(4-oxo-7-((tetrahydrofuran-3-yl)oxy)-1,4-dihydroquinazolin-6-yl)but-2-enamide hydrochloride
Description Afatinib Impurity J (CAS No: 1456696-14-2) is a degradation product of afatinib that is an anilinoquinazoline derivative having irreversible tyrosine kinase receptor inhibition activity utilized for the treatment of metastatic non-small cell lung cancer.
References Chavan, Balasaheb B., et al. “Isolation and Structural Characterization of Degradation Products of Afatinib Dimaleate by LC-Q-TOF/MS/MS and NMR: Cytotoxicity Evaluation of Afatinib and Isolated Degradation Products.” Journal of Pharmaceutical and Biomedical Analysis, vol. 166, Mar. 2019, pp. 139–46, https://doi.org/10.1016/j.jpba.2019.01.004.

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