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Agomelatine Desmethyl Impurity

Agomelatine Desmethyl Impurity

Catalogue No.: VL1840009
CAS No.: 152302-45-9

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Name: Agomelatine Desmethyl Impurity
Catalogue No. VL1840009
CAS No. 152302-45-9
Molecular Formula C14H15NO2
Molecular Weight 229.28
Status Under Development
IUPAC Name N-[2-(7-Hydroxy-1-naphthalenyl)ethyl]acetamide
Synonyms 7-Desmethyl Agomelatine
Description Agomelatine Desmethyl Impurity (CAS No: 152302-45-9) or 7-Desmethyl Agomelatine chemically known as N-[2-(7-Hydroxy-1-naphthalenyl)ethyl]acetamide is a degradation product and an impurity of Agomelatine that has 5-hydrotryptamine 2C (5-HT2c) antagonist properties.
References Liu, Yaxuan, et al. “Quantification and Structural Elucidation of Potential Impurities in Agomelatine Active Pharmaceutical Ingredient.” Journal of Pharmaceutical and Biomedical Analysis, vol. 81-82, July 2013, pp. 193–201, https://doi.org/10.1016/j.jpba.2013.04.016. Somana, Siva, et al. “QBD BASED ANALYTICAL METHOD DEVELOPMENT and VALIDATION for the SEPARATION and QUANTIFICATION of AGOMELATINE and ITS IMPURITIES in SOLID ORAL DOSAGE FORMS USING HPLC.” Rasayan J. Chem, vol. 14, no. 3, 2183, p. 2

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