| Name: | Aliskiren 4-O-Desmethyl Impurity |
| Catalogue No. | VL5780004 |
| CAS No. | 949925-74-0 |
| Molecular Formula | C29H51N3O6 |
| Molecular Weight | 537.73 g/mol |
| Status | In-Stock |
| IUPAC Name | (αS,γS,δS,ζS)-δ-Amino-N-(3-amino-2,2-dimethyl-3-oxopropyl)-γ,4-dihydroxy-3-(3-methoxypropoxy)-α,ζ-bis(1-methylethyl)benzeneoctanamide |
| Description | Aliskiren 4-O-Desmethyl Impurity (CAS No: 949925-74-0) is a degradation product of Aliskiren that is a pharmacotherapeutic class of renin inhibitors that is utilized in the therapy of essential hypertension. It functions by selectively inhibiting the renin that is efficient in the transformation of angiotensinogen to angiotensin-I. |
| References | Kushwah, Bhoopendra Singh, et al. “Characterization of Solution Stress Degradation Products of Aliskiren and Prediction of Their Physicochemical and ADMET Properties.” European Journal of Pharmaceutical Sciences, vol. 121, Aug. 2018, pp. 139–54,https://doi.org/10.1016/j.ejps.2018.05.021.Ashok, S., et al. “A Validated LC Method for the Determination of the Enantiomeric Purity of Aliskiren Hemifumarate in Bulk Drug Samples.” Journal of Chromatographic Science, June 2012,https://doi.org/10.1093/chr |
