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Aliskiren 4-O-Desmethyl Impurity

Aliskiren 4-O-Desmethyl Impurity

Catalogue No.: VL5780004
CAS No.: 949925-74-0

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Name: Aliskiren 4-O-Desmethyl Impurity
Catalogue No. VL5780004
CAS No. 949925-74-0
Molecular Formula C29H51N3O6
Molecular Weight 537.73 g/mol
Status In-Stock
IUPAC Name (αS,γS,δS,ζS)-δ-Amino-N-(3-amino-2,2-dimethyl-3-oxopropyl)-γ,4-dihydroxy-3-(3-methoxypropoxy)-α,ζ-bis(1-methylethyl)benzeneoctanamide
Description Aliskiren 4-O-Desmethyl Impurity (CAS No: 949925-74-0) is a degradation product of Aliskiren that is a pharmacotherapeutic class of renin inhibitors that is utilized in the therapy of essential hypertension. It functions by selectively inhibiting the renin that is efficient in the transformation of angiotensinogen to angiotensin-I.
References Kushwah, Bhoopendra Singh, et al. “Characterization of Solution Stress Degradation Products of Aliskiren and Prediction of Their Physicochemical and ADMET Properties.” European Journal of Pharmaceutical Sciences, vol. 121, Aug. 2018, pp. 139–54,https://doi.org/10.1016/j.ejps.2018.05.021.Ashok, S., et al. “A Validated LC Method for the Determination of the Enantiomeric Purity of Aliskiren Hemifumarate in Bulk Drug Samples.” Journal of Chromatographic Science, June 2012,https://doi.org/10.1093/chr

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