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Aliskiren 8-Hydroxy Impurity

Aliskiren 8-Hydroxy Impurity

Catalogue No.: VL5780002
CAS No.: 1438401-04-7

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Name: Aliskiren 8-Hydroxy Impurity
Catalogue No. VL5780002
CAS No. 1438401-04-7
Molecular Formula C30H53N3O7
Molecular Weight 567.76 g/mol
Status In-Stock
IUPAC Name (αS,γS,δS,ζS)-δ-Amino-N-(3-amino-2,2-dimethyl-3-oxopropyl)-γ,η-dihydroxy-4-methoxy-3-(3-methoxypropoxy)-α,ζ-bis(1-methylethyl)benzeneoctanamide hemifumarate
Description Aliskiren 8-Hydroxy Impurity (CAS No: 1438401-04-7) is a derivative of Aliskiren that belongs to the pharmacotherapeutic class of renin inhibitors that is utilized in the therapy of essential hypertension. It acts by that works by selectively inhibiting renin that is an enzyme used for the conversion of angiotensinogen to angiotensin-I.
References Kushwah, Bhoopendra Singh, et al. “Characterization of Solution Stress Degradation Products of Aliskiren and Prediction of Their Physicochemical and ADMET Properties.” European Journal of Pharmaceutical Sciences, vol. 121, Aug. 2018, pp. 139–54,https://doi.org/10.1016/j.ejps.2018.05.021.Ashok, S., et al. “A Validated LC Method for the Determination of the Enantiomeric Purity of Aliskiren Hemifumarate in Bulk Drug Samples.” Journal of Chromatographic Science, June 2012,https://doi.org/10.1093/chr

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