| Name: | Aliskiren 8-Hydroxy Impurity |
| Catalogue No. | VL5780002 |
| CAS No. | 1438401-04-7 |
| Molecular Formula | C30H53N3O7 |
| Molecular Weight | 567.76 g/mol |
| Status | In-Stock |
| IUPAC Name | (αS,γS,δS,ζS)-δ-Amino-N-(3-amino-2,2-dimethyl-3-oxopropyl)-γ,η-dihydroxy-4-methoxy-3-(3-methoxypropoxy)-α,ζ-bis(1-methylethyl)benzeneoctanamide hemifumarate |
| Description | Aliskiren 8-Hydroxy Impurity (CAS No: 1438401-04-7) is a derivative of Aliskiren that belongs to the pharmacotherapeutic class of renin inhibitors that is utilized in the therapy of essential hypertension. It acts by that works by selectively inhibiting renin that is an enzyme used for the conversion of angiotensinogen to angiotensin-I. |
| References | Kushwah, Bhoopendra Singh, et al. “Characterization of Solution Stress Degradation Products of Aliskiren and Prediction of Their Physicochemical and ADMET Properties.” European Journal of Pharmaceutical Sciences, vol. 121, Aug. 2018, pp. 139–54,https://doi.org/10.1016/j.ejps.2018.05.021.Ashok, S., et al. “A Validated LC Method for the Determination of the Enantiomeric Purity of Aliskiren Hemifumarate in Bulk Drug Samples.” Journal of Chromatographic Science, June 2012,https://doi.org/10.1093/chr |
