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Alvimopan Impurity 6

Alvimopan Impurity 6

Catalogue No.: VL5980005
CAS No.: 1420776-96-0

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Name: Alvimopan Impurity 6
Catalogue No. VL5980005
CAS No. 1420776-96-0
Molecular Formula C24H29NO3 . HCl
Molecular Weight 379.50 36.46 g/mol
Status In-Stock
IUPAC Name (E)-methyl 2-(((3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethylpiperidin-1-yl)methyl)-3-phenylacrylate hydrochloride
Description Alvimopan Impurity 6 (CAS No: 1420776-96-0) is an impurity observed in Alvimopan that is an opioid drug that acts peripherally by antagonist mu-opioid receptor (PAM-OR) and is utilised in the treatment of postoperative ileus. It is also used in the treatment of post-operative ileus and chronic idiopathic constipation.
References Ramalinga Reddy, Beeravalli, et al. “Synthesis and Characterization of All Possible Diastereoisomers of Alvimopan.” Oriental Journal of Chemistry, vol. 34, no. 2, Apr. 2018, pp. 963–72,https://doi.org/10.13005/ojc/340246.Baira, Shandilya Mahamuni, et al. “Identification and Structural Characterization of Hydrolytic Degradation Products of Alvimopan by LC/QTOF/MS/MS and NMR Studies.” Journal of Pharmaceutical and Biomedical Analysis, vol. 165, Feb. 2019, pp. 399–409,https://doi.org/10.1016/j.jpba

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