| Name: | Ambrisentan Methyl Ester |
| Catalogue No. | VL6020018 |
| CAS No. | 1106685-61-3 |
| Molecular Formula | C23H24N2O4 |
| Molecular Weight | 392.45 g/mol |
| Status | In-Stock |
| IUPAC Name | (+)-(2S)-2-[(4,6-Dimethylpyrimidin-2-yl)oxy]-3-methoxy-3,3-diphenyl propanoic acid methyl ester |
| Description | Ambrisentan Methyl Ester (CAS No: 1106685-61-3) or (+)-(2S)-2-[(4,6-Dimethylpyrimidin-2-yl)oxy]-3-methoxy-3,3-diphenyl propanoic acid methyl ester is an intermediate formed during the synthesis of Ambrisentan that is a nonsulfonamide class endothelin receptor antagonist employed for the treatment of pulmonary arterial hypertension. |
| References | Feng, Wei-Dong, et al. “Isolation, Identification, Characterization, Synthesis and Quality Control Strategy of New Process-Related Impurities in Ambrisentan.” Journal of Pharmaceutical and Biomedical Analysis, vol. 165, Feb. 2019, pp. 325–37,https://doi.org/10.1016/j.jpba.2018.12.008.Pasquini, Benedetta, et al. “Combined Approach Using Capillary Electrophoresis, NMR and Molecular Modeling for Ambrisentan Related Substances Analysis: Investigation of Intermolecular Affinities, Complexation and Se |
