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Ambrisentan Methyl Ester

Ambrisentan Methyl Ester

Catalogue No.: VL6020018
CAS No.: 1106685-61-3

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Name: Ambrisentan Methyl Ester
Catalogue No. VL6020018
CAS No. 1106685-61-3
Molecular Formula C23H24N2O4
Molecular Weight 392.45 g/mol
Status In-Stock
IUPAC Name (+)-(2S)-2-[(4,6-Dimethylpyrimidin-2-yl)oxy]-3-methoxy-3,3-diphenyl propanoic acid methyl ester
Description Ambrisentan Methyl Ester (CAS No: 1106685-61-3) or (+)-(2S)-2-[(4,6-Dimethylpyrimidin-2-yl)oxy]-3-methoxy-3,3-diphenyl propanoic acid methyl ester is an intermediate formed during the synthesis of Ambrisentan that is a nonsulfonamide class endothelin receptor antagonist employed for the treatment of pulmonary arterial hypertension.
References Feng, Wei-Dong, et al. “Isolation, Identification, Characterization, Synthesis and Quality Control Strategy of New Process-Related Impurities in Ambrisentan.” Journal of Pharmaceutical and Biomedical Analysis, vol. 165, Feb. 2019, pp. 325–37,https://doi.org/10.1016/j.jpba.2018.12.008.Pasquini, Benedetta, et al. “Combined Approach Using Capillary Electrophoresis, NMR and Molecular Modeling for Ambrisentan Related Substances Analysis: Investigation of Intermolecular Affinities, Complexation and Se

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