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Ambrisentan (R)-Isomer

Ambrisentan (R)-Isomer

Catalogue No.: VE007941
CAS No.: 1007358-76-0

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Name: Ambrisentan (R)-Isomer
Catalogue No. VE007941
CAS No. 1007358-76-0
Molecular Formula C22H22N2O4
Molecular Weight 378.42 g/mol
Status In-Stock
IUPAC Name (-)-(2R)-2-[(4,6-Dimethylpyrimidin-2-yl)oxy]-3-methoxy-3,3-diphenyl propanoic acid ; (R)-2-((4,6-Dimethylpyrimidin-2-yl)oxy)-3-methoxy-3,3-diphenylpropanoic Acid
Description Ambrisentan (R)-Isomer (CAS No: 1007358-76-0) chemically known as (-)-(2R)-2-[(4,6-Dimethylpyrimidin-2-yl)oxy]-3-methoxy-3,3-diphenyl propanoic acid is an enantiomer of S-ambrisentan that is a chiral drug used for the treatment of pulmonary arterial hypertension and in the therapy of migraine and cluster headaches.
References Pasquini, Benedetta, et al. “Combined Approach Using Capillary Electrophoresis, NMR and Molecular Modeling for Ambrisentan Related Substances Analysis: Investigation of Intermolecular Affinities, Complexation and Separation Mechanism.” Journal of Pharmaceutical and Biomedical Analysis, vol. 144, Sept. 2017, pp. 220–29,https://doi.org/10.1016/j.jpba.2017.01.038.

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