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Ambrisentan Vinyloxy Impurity

Ambrisentan Vinyloxy Impurity

Catalogue No.: VL6020011
CAS No.: 1639429-81-4

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Name: Ambrisentan Vinyloxy Impurity
Catalogue No. VL6020011
CAS No. 1639429-81-4
Molecular Formula C20H18N2O
Molecular Weight 302.38 g/mol
Status In-Stock
IUPAC Name 2-((2,2-diphenylvinyl)oxy)-4,6-dimethylpyrimidine
Description Ambrisentan Vinyloxy Impurity (CAS No: 1639429-81-4) or 2-((2,2-diphenylvinyl)oxy)-4,6-dimethylpyrimidine is an impurity formed during the synthesis of Ambrisentan that is used in the treatment of pulmonary arterial hypertension (PAH) that acts by blocking the effects of a substance called endothelin, which is generated by the body in increased amounts in patients with PAH
References Narayana, M. B. V., et al. “A Validated Specific Stability-Indicating RP-HPLC Assay Method for Ambrisentan and Its Related Substances.” Journal of Chromatographic Science, vol. 52, no. 8, Aug. 2013, pp. 818–25,https://doi.org/10.1093/chromsci/bmt121.

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