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Atorvastatin Pyrrolidone Analog

Atorvastatin Pyrrolidone Analog

Catalogue No.: VL10019
CAS No.: 148217-40-7

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Name: Atorvastatin Pyrrolidone Analog
Catalogue No. VL10019
CAS No. 148217-40-7
Molecular Formula C33H35FN2O6
Molecular Weight 574.25
Status In-stock
IUPAC Name (3R,5R)-7-[5-(4-Fluorophenyl)-2,3-dihydro-3-(1-methylethyl)-2- oxo- 4-phenyl-3-[(phenylamino) carbon
Synonyms Atorvastatin Lactam
Appearance White Solid
Description Atorvastatin Pyrrolidone Analog (USP) / Atorvastatin Lactam(CAS No: 148217-40-7) or (3R,5R)-7-[5-(4-Fluorophenyl)-2,3-dihydro-3-(1-methylethyl)-2- oxo- 4-phenyl-3-[(phenylamino) carbonyl]-1H-pyrrol-1-yl]-3,5- dihydroxy-heptanoic acid Sodium salt is an impurity of atorvastatin. it is rapidly absorbed after oral administration with a peak plasma concentration at 1 to 2 hours. The bioavailability is low at 14% due to extensive first-pass metabolism.
References McIver, Lindsey A., and Momin S. Siddique. “Atorvastatin.” Nih.gov, StatPearls Publishing, 5 Jan. 2019, www.ncbi.nlm.nih.gov/books/NBK430779/ Black, Donald M., et al. “An Overview of the Clinical Safety Profile of Atorvastatin (Lipitor), a New HMG-CoA Reductase Inhibitor.” Archives of Internal Medicine, vol. 158, no. 6, Mar. 1998, p. 577, https://doi.org/10.1001/archinte.158.6.577.

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