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Cetirizine 4-chlorobenzhydrol Impurity

Cetirizine 4-chlorobenzhydrol Impurity

Catalogue No.: VL330010
CAS No.: 119-56-2

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Name: Cetirizine 4-chlorobenzhydrol Impurity
Catalogue No. VL330010
CAS No. 119-56-2
Molecular Formula C17H26ClNO2
Molecular Weight 311.85
Status In-stock
IUPAC Name (5RS)-5-(4-Methoxyphenyl)-3-methyl-1-oxa-3- azaspiro-[5.5]undecane Hydrochloride
Synonyms Meclizine Related Compound A
Appearance White solid
Description Cetirizine 4 chlorobenzhydrol Impurity (CAS No: 119-56-2) or (4-Chlorophenyl)phenyl methanol is a key pharmaceutical intermediate for the synthesis of bepotastine and cloperastine. It has a central antitussive effect and antiedemic effect and is endowed with an antihistaminic activity that acts as a mild bronchorelaxant.
References Wu, Kai, et al. “Efficient Synthesis of Bepotastine and Cloperastine Intermediates Using Engineered Alcohol Dehydrogenase with a Hydrophobic Pocket.” Applied Microbiology and Biotechnology, vol. 105, no. 14-15, Aug. 2021, pp. 5873–82, https://doi.org/10.1007/s00253-021-11413-9. ‌Cuzzocrea, Salvator, and Maria Catania. “Pharmacological and Clinical Overview of Cloperastine in Treatment of Cough.” Therapeutics and Clinical Risk Management, Mar. 2011, p. 83, https://doi.org/10.2147/tcrm.s16643. ‌

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