
Name: | Cetirizine 4-chlorobenzhydrol Impurity |
Catalogue No. | VL330010 |
CAS No. | 119-56-2 |
Molecular Formula | C17H26ClNO2 |
Molecular Weight | 311.85 |
Status | In-stock |
IUPAC Name | (5RS)-5-(4-Methoxyphenyl)-3-methyl-1-oxa-3- azaspiro-[5.5]undecane Hydrochloride |
Synonyms | Meclizine Related Compound A |
Appearance | White solid |
Description | Cetirizine 4 chlorobenzhydrol Impurity (CAS No: 119-56-2) or (4-Chlorophenyl)phenyl methanol is a key pharmaceutical intermediate for the synthesis of bepotastine and cloperastine. It has a central antitussive effect and antiedemic effect and is endowed with an antihistaminic activity that acts as a mild bronchorelaxant. |
References | Wu, Kai, et al. “Efficient Synthesis of Bepotastine and Cloperastine Intermediates Using Engineered Alcohol Dehydrogenase with a Hydrophobic Pocket.” Applied Microbiology and Biotechnology, vol. 105, no. 14-15, Aug. 2021, pp. 5873–82, https://doi.org/10.1007/s00253-021-11413-9. Cuzzocrea, Salvator, and Maria Catania. “Pharmacological and Clinical Overview of Cloperastine in Treatment of Cough.” Therapeutics and Clinical Risk Management, Mar. 2011, p. 83, https://doi.org/10.2147/tcrm.s16643. |