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Chlortalidone Impurity J

Chlortalidone Impurity J

Catalogue No.: VL1090011
CAS No.: 956-92-3

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Name: Chlortalidone Impurity J
Catalogue No. VL1090011
CAS No. 956-92-3
Molecular Formula C₁₄H₁₀ClNO₂
Molecular Weight 259.69
Status In-Stock
IUPAC Name 3-(4-Chlorophenyl)-2,3-dihydro-3-hydroxy-1H-isoindol-1-one
Description Chlortalidone Impurity J (CAS No: 956-92-3) or 3-(4-Chlorophenyl)-2,3-dihydro-3-hydroxy-1H-isoindol-1-one is an analog of Chlorthalidone that has potential hyperglycemic and antidiuretic activities. Chlorthalidone promotes mineral retention in patients with idiopathic hypercalciuria. Chlorthalidone has proven efficacy to reduce cardiovascular morbidity and mortality.
References Wales, J. K., et al. “The Hyperglycemic and Antidiuretic Activity of a Phthalimidine Analogue: 1-Oxo-3-(4’-Chlorophenyl)-3-Hydroxyisoindoline (C3/76).” Experimental Biology and Medicine, vol. 128, no. 2, June 1968, pp. 581–87, https://doi.org/10.3181/00379727-128-33072. Coe, Fredric L., et al. “Chlorthalidone Promotes Mineral Retention in Patients with Idiopathic Hypercalciuria.” Kidney International, vol. 33, no. 6, June 1988, pp. 1140–46, https://doi.org/10.1038/ki.1988.122. Bakris, George L.,

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