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Cimetidine EP Impurity B

Cimetidine EP Impurity B

Catalogue No.: VL1900002
CAS No.: 138035-55-9

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Name: Cimetidine EP Impurity B
Catalogue No. VL1900002
CAS No. 138035-55-9
Molecular Formula C10H15N5OS
Molecular Weight 253.32
Status In-stock
IUPAC Name Methyl 3-cyano-1-[2-[[(5-methyl-1H-imidazol-4-yl)methyl]sulfanyl]ethyl]-carbamimidate
Synonyms Cimetidine Methoxy Analog
Appearance White Solid powder
Description Cimetidine EP Impurity B (CAS No: 138035-55-9) or Methyl 3-cyano-1-[2-[[(5-methyl-1H-imidazol-4-yl)methyl]sulfanyl]ethyl]-carbamimidate is a Methoxy Analog of Cimetidine. Cimetidine lowers the blood flow in the liver and the systemic clearance of drugs like propranolol which are highly extracted by the liver. Cimetidine is an H2-receptor antagonist and has depicted the ability to enhance a variety of immunologic functions both in vivo and in vitro due to its inhibitory effects on suppressor-cell
References Paxton, J. W., et al. “The Effect of Cimetidine, Phenobarbitone and Buthionine Sulphoximine on the Disposition of N-5-Dimethyl-9-[(2-Methoxy-4-Methyl-Sulphonylamino) Phenylamino]-4-Acridinecarboxamide (CI-921) in the Rabbit.” Cancer Chemotherapy and Pharmacology, vol. 23, no. 5, May 1989, pp. 291–95, https://doi.org/10.1007/bf00292406. “Increased Toxicity and Reduced Clearance of Lidocaine by Cimetidine | Annals of Internal Medicine.” Annals of Internal Medicine, 2021, www.acpjournals.org/doi/

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