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Cimetidine EP Impurity C (free base)

Cimetidine EP Impurity C (free base)

Catalogue No.: VE006610
CAS No.: 77076-18-7

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Name: Cimetidine EP Impurity C (free base)
Catalogue No. VE006610
CAS No. 77076-18-7
Molecular Formula C10H18N6OS
Molecular Weight 270.4
Status In-stock
IUPAC Name 1-[(Methylamino)-[[2-[[(5-methyl-1H-imidazol-4-yl)methyl]sulfanyl]-ethyl] amino]methylidene]urea
Synonyms Cimetidine Amide Impurity
Appearance White Solid
Description Cimetidine EP Impurity C (free base) (CAS No: 77076-18-7) or Cimetidine Amide Impurity is a minor impurity in Cimetidine. Cimetidine blocks microsomal metabolism. Due to this, cimetidine impairs the deletion of oral anticoagulants and the drug antipyrine from the bloodstream. Cimetidine is among the most widely used drugs. The ability of cimetidine to block histamine stimulated acid secretion is due to its antagonistic effect at H2 receptors of parietal cells.
References Liang, Xiufang, et al. “Characterization of Drug-Related Impurities Using UPLC-QTrap-MS/MS in Three Scan Modes: Application to Daptomycin.” International Journal of Mass Spectrometry, vol. 468, Oct. 2021, p. 116657, https://doi.org/10.1016/j.ijms.2021.116657. Klotz, Ulrich, and Ingrid Reimann. “Delayed Clearance of Diazepam due to Cimetidine.” New England Journal of Medicine, vol. 302, no. 18, May 1980, pp. 1012–14, https://doi.org/10.1056/nejm198005013021807. Koch-Weser, Jan, et al. “Cimeti

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