| Name: | Cimetidine EP Impurity G |
| Catalogue No. | VE006613 |
| CAS No. | 1609-06-9 |
| Molecular Formula | C4H8N4 |
| Molecular Weight | 112.13 |
| Status | In-stock |
| IUPAC Name | 2-Cyano-1,3-dimethylguanidine |
| Description | Cimetidine EP Impurity G (CAS No: 1609-06-9) or 2-Cyano-1,3-dimethylguanidine is a nitrosoguanidine analog of Cimetidine. Cimetidine is a H2 receptor antagonist. It is commonly evaluated for gastric and duodenal ulcer disease. Cimetidine is known to have anticancer effects. Cimetidine has the ability to alter tumor cell adhesion, angiogenesis, and proliferation. It shows an effect on the immune system and inhibition of postoperative immunosuppression. |
| References | Hansson, Lars O., et al. “Structural Determinants in Domain II of Human Glutathione Transferase M2-2 Govern the Characteristic Activities with Aminochrome, 2-Cyano-1, 3-Dimethyl-1-Nitrosoguanidine, and 1, 2-Dichloro-4-Nitrobenzene.” Protein Science, vol. 8, no. 12, Dec. 2008, pp. 2742–50, https://doi.org/10.1110/ps.8.12.2742. Kubecova, Martina, et al. “Cimetidine: An Anticancer Drug?” European Journal of Pharmaceutical Sciences, vol. 42, no. 5, Apr. 2011, pp. 439–44, https://doi.org/10.1016/j.e |
