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Cimetidine EP Impurity H

Cimetidine EP Impurity H

Catalogue No.: VE006614
CAS No.: 74886-59-2

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Name: Cimetidine EP Impurity H
Catalogue No. VE006614
CAS No. 74886-59-2
Molecular Formula C10H18N8S2
Molecular Weight 314.43
Status In-stock
IUPAC Name 1,1′-(Disulfanediyldiethylene)bis(2-cyano-3-methylguanidine)
Synonyms Cimetidine Disulfane Impurity
Appearance White to Off-White Solid
Description Cimetidine EP Impurity H (CAS No: 74886-59-2) or Cimetidine Disulfane Impurity is an impurity of Cimetidine. It depicts an H2-receptor antagonistic property that is evaluated for the treatment and prevention of stress-induced gastroduodenal lesions. Cimetidine is a non-thiourea analogue of metiamide. It is a specific competitive histamine H2-receptor antagonist and is a good gastric secretion inhibitor in animals and humans.
References Kauffman, Gordon L., and Morton I. Grossman. “Prostaglandin and Cimetidine Inhibit the Formation of Ulcers Produced by Parenteral Salicylates.” Gastroenterology, vol. 75, no. 6, Dec. 1978, pp. 1099–102, https://doi.org/10.1016/0016-5085(78)90082-3. “Cimetidine for Prevention and Treatment of Gastroduodenal Mucosal Lesions in Patients in an Intensive Care Unit | Annals of Internal Medicine.” Annals of Internal Medicine, 2021, www.acpjournals.org/doi/abs/10.7326/0003-4819-103-2-173. Brimblecombe

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