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Cinacalcet Impurity A

Cinacalcet Impurity A

Catalogue No.: VL231001
CAS No.: 3886-70-2

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Name: Cinacalcet Impurity A
Catalogue No. VL231001
CAS No. 3886-70-2
Molecular Formula C12H13N
Molecular Weight 171.24
Status In-stock
IUPAC Name (R)-1-(naphthalen-1-yl)ethanamine
Synonyms Naphthyl Ethylamine / Amine
Description Cinacalcet Impurity A (CAS No: 3886-70-2) or Naphthyl Ethylamine / Amine is a calcimimetic agent. It is a metabolite of Cinacalcet. Cinacalcet impedes serum calcium in kidney transplant patients with hypercalcemic hyperparathyroidism. Cinacalcet raises renal deletion of calcium and therefore betters hypercalcemia in kidney transplant recipients. The calcium lowering effect of cinacalcet in patients with hyperparathyroidism post kidney transplantation is due to elevated urinary calcium excretion.
References Thiel, Oliver R., et al. “Practical Synthesis of the Calcimimetic Agent, Cinacalcet.” Tetrahedron Letters, vol. 49, no. 1, Jan. 2008, pp. 13–15, https://doi.org/10.1016/j.tetlet.2007.11.030. ‌Borchhardt, Kyra A., et al. “Cinacalcet Increases Calcium Excretion in Hypercalcemic Hyperparathyroidism after Kidney Transplantation.” Transplantation, vol. 86, no. 7, Oct. 2008, pp. 919–24, https://doi.org/10.1097/tp.0b013e318186b7fb.

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