
Name: | Cinacalcet Impurity F |
Catalogue No. | VL231006 |
CAS No. | 1271930-12-1 |
Molecular Formula | C22H28F3N |
Molecular Weight | 363.46 |
Status | In-stock |
IUPAC Name | N-((R)-1-(naphthalen-1-yl)ethyl)-3-(3-(trifluoromethyl)cyclohexyl)propan-1-amine |
Synonyms | Cinacalcet E- Isomer / Cinacalcet E- Oxime / Hexahydrophenyl Cinacalcet |
Appearance | Off White Powder |
Description | Cinacalcet Impurity F (CAS No: 1271930-12-1) or Cinacalcet E- Isomer / Cinacalcet E- Oxime / Hexahydrophenyl Cinacalcet is an E isomer of Cinacalcet. Calcimimetics like cinacalcet target the calcium-sensing receptor and impede parathyroid hormone levels without elevating calcium and phosphorus levels. |
References | Prediger, Patrícia, et al. “Construction of 3-Arylpropylamines Using Heck Arylations. The Total Synthesis of Cinacalcet Hydrochloride, Alverine, and Tolpropamine.” Tetrahedron, vol. 70, no. 20, May 2014, pp. 3333–41, https://doi.org/10.1016/j.tet.2013.10.014. Block, Geoffrey A., et al. “Cinacalcet for Secondary Hyperparathyroidism in Patients Receiving Hemodialysis.” New England Journal of Medicine, vol. 350, no. 15, Apr. 2004, pp. 1516–25, https://doi.org/10.1056/nejmoa031633. |