| Name: | Cinacalcet Impurity F |
| Catalogue No. | VL231006 |
| CAS No. | 1271930-12-1 |
| Molecular Formula | C22H28F3N |
| Molecular Weight | 363.46 |
| Status | In-stock |
| IUPAC Name | N-((R)-1-(naphthalen-1-yl)ethyl)-3-(3-(trifluoromethyl)cyclohexyl)propan-1-amine |
| Synonyms | Cinacalcet E- Isomer / Cinacalcet E- Oxime / Hexahydrophenyl Cinacalcet |
| Appearance | Off White Powder |
| Description | Cinacalcet Impurity F (CAS No: 1271930-12-1) or Cinacalcet E- Isomer / Cinacalcet E- Oxime / Hexahydrophenyl Cinacalcet is an E isomer of Cinacalcet. Calcimimetics like cinacalcet target the calcium-sensing receptor and impede parathyroid hormone levels without elevating calcium and phosphorus levels. |
| References | Prediger, Patrícia, et al. “Construction of 3-Arylpropylamines Using Heck Arylations. The Total Synthesis of Cinacalcet Hydrochloride, Alverine, and Tolpropamine.” Tetrahedron, vol. 70, no. 20, May 2014, pp. 3333–41, https://doi.org/10.1016/j.tet.2013.10.014. Block, Geoffrey A., et al. “Cinacalcet for Secondary Hyperparathyroidism in Patients Receiving Hemodialysis.” New England Journal of Medicine, vol. 350, no. 15, Apr. 2004, pp. 1516–25, https://doi.org/10.1056/nejmoa031633. |
