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Cinacalcet Impurity F

Cinacalcet Impurity F

Catalogue No.: VL231006
CAS No.: 1271930-12-1

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Name: Cinacalcet Impurity F
Catalogue No. VL231006
CAS No. 1271930-12-1
Molecular Formula C22H28F3N
Molecular Weight 363.46
Status In-stock
IUPAC Name N-((R)-1-(naphthalen-1-yl)ethyl)-3-(3-(trifluoromethyl)cyclohexyl)propan-1-amine
Synonyms Cinacalcet E- Isomer / Cinacalcet E- Oxime / Hexahydrophenyl Cinacalcet
Appearance Off White Powder
Description Cinacalcet Impurity F (CAS No: 1271930-12-1) or Cinacalcet E- Isomer / Cinacalcet E- Oxime / Hexahydrophenyl Cinacalcet is an E isomer of Cinacalcet. Calcimimetics like cinacalcet target the calcium-sensing receptor and impede parathyroid hormone levels without elevating calcium and phosphorus levels.
References Prediger, Patrícia, et al. “Construction of 3-Arylpropylamines Using Heck Arylations. The Total Synthesis of Cinacalcet Hydrochloride, Alverine, and Tolpropamine.” Tetrahedron, vol. 70, no. 20, May 2014, pp. 3333–41, https://doi.org/10.1016/j.tet.2013.10.014. ‌Block, Geoffrey A., et al. “Cinacalcet for Secondary Hyperparathyroidism in Patients Receiving Hemodialysis.” New England Journal of Medicine, vol. 350, no. 15, Apr. 2004, pp. 1516–25, https://doi.org/10.1056/nejmoa031633.

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