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Cinacalcet Impurity G

Cinacalcet Impurity G

Catalogue No.: VL2310035
CAS No.: 1428185-71-0

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Name: Cinacalcet Impurity G
Catalogue No. VL2310035
CAS No. 1428185-71-0
Molecular Formula C₂₂H₂₂F₃N
Molecular Weight 357.41
Status In-stock
IUPAC Name (αR)-α-Methyl-N-[3-[4-(trifluoromethyl)phenyl]propyl]-1-naphthalenemethan amine
Description Cinacalcet Impurity G (CAS No: 1428185-71-0) or (αR)-α-Methyl-N-[3-[4-(trifluoromethyl)phenyl]propyl]-1-naphthalenemethan amine is a compound of Cinacalcetd that acts as a calcimimetic. It is evaluated to treat secondary hyperparathyroidis. The calcimimetic cinacalcet acts on the calcium-sensing receptor to elevate its sensitivity to calcium, thereby lower parathyroid hormone secretion. Cinacalcet impedes circulating PTH levels by raising the sensitivity of the CaR to extracellular calcium.
References Block, Geoffrey A., et al. “Cinacalcet for Secondary Hyperparathyroidism in Patients Receiving Hemodialysis.” New England Journal of Medicine, vol. 350, no. 15, Apr. 2004, pp. 1516–25, https://doi.org/10.1056/nejmoa031633. “Cinacalcet HCl: A Calcimimetic Agent for the Management of Primary and Secondary Hyperparathyroidism.” Expert Opinion on Investigational Drugs, 2021, www.tandfonline.com/doi/abs/10.1517/13543784.12.8.1413. “Cymitquimica.” Cymitquimica.com, 2019, cymitquimica.com/products/TR-M

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