| Name: | Cinacalcet Impurity G |
| Catalogue No. | VL2310035 |
| CAS No. | 1428185-71-0 |
| Molecular Formula | C₂₂H₂₂F₃N |
| Molecular Weight | 357.41 |
| Status | In-stock |
| IUPAC Name | (αR)-α-Methyl-N-[3-[4-(trifluoromethyl)phenyl]propyl]-1-naphthalenemethan amine |
| Description | Cinacalcet Impurity G (CAS No: 1428185-71-0) or (αR)-α-Methyl-N-[3-[4-(trifluoromethyl)phenyl]propyl]-1-naphthalenemethan amine is a compound of Cinacalcetd that acts as a calcimimetic. It is evaluated to treat secondary hyperparathyroidis. The calcimimetic cinacalcet acts on the calcium-sensing receptor to elevate its sensitivity to calcium, thereby lower parathyroid hormone secretion. Cinacalcet impedes circulating PTH levels by raising the sensitivity of the CaR to extracellular calcium. |
| References | Block, Geoffrey A., et al. “Cinacalcet for Secondary Hyperparathyroidism in Patients Receiving Hemodialysis.” New England Journal of Medicine, vol. 350, no. 15, Apr. 2004, pp. 1516–25, https://doi.org/10.1056/nejmoa031633. “Cinacalcet HCl: A Calcimimetic Agent for the Management of Primary and Secondary Hyperparathyroidism.” Expert Opinion on Investigational Drugs, 2021, www.tandfonline.com/doi/abs/10.1517/13543784.12.8.1413. “Cymitquimica.” Cymitquimica.com, 2019, cymitquimica.com/products/TR-M |
