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Cinacalcet N Oxide Impurity

Cinacalcet N Oxide Impurity

Catalogue No.: VL2310016
CAS No.: 1229224-94-5

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Name: Cinacalcet N Oxide Impurity
Catalogue No. VL2310016
CAS No. 1229224-94-5
Molecular Formula C22H22F3NO
Molecular Weight 373.41
Status In-stock
IUPAC Name (R)-N-(1-(Naphthalen-1-yl)ethyl)-3-(3-(trifluoromethyl) phenyl)propan-1-amine N-oxide
Appearance White solid
Description Cinacalcet N Oxide Impurity (CAS No: 1229224-94-5) or (R)-N-(1-(Naphthalen-1-yl)ethyl)-3-(3-(trifluoromethyl) phenyl)propan-1-amine N-oxide is an amine adulteration compound of Cinacalcet. The cinacalcet acts on the calcium-sensing receptor to elevate its sensitivity to calcium and therefore lowers the parathyroid hormone (PTH) secretion. Cinacalcet impedes circulating PTH levels by raising the sensitivity of the CaR to extracellular calcium.
References Shah, Mansi, et al. “Capillary Electrophoresis Methods for Impurity Profiling of Drugs: A Review of the Past Decade.” Journal of Pharmaceutical Analysis, July 2021, https://doi.org/10.1016/j.jpha.2021.06.009. Lindberg, Jill S., et al. “Cinacalcet HCl, an Oral Calcimimetic Agent for the Treatment of Secondary Hyperparathyroidism in Hemodialysis and Peritoneal Dialysis: A Randomized, Double-Blind, Multicenter Study.” Journal of the American Society of Nephrology, vol. 16, no. 3, Feb. 2005, pp. 800

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