| Name: | Cinacalcet N Oxide Impurity |
| Catalogue No. | VL2310016 |
| CAS No. | 1229224-94-5 |
| Molecular Formula | C22H22F3NO |
| Molecular Weight | 373.41 |
| Status | In-stock |
| IUPAC Name | (R)-N-(1-(Naphthalen-1-yl)ethyl)-3-(3-(trifluoromethyl) phenyl)propan-1-amine N-oxide |
| Appearance | White solid |
| Description | Cinacalcet N Oxide Impurity (CAS No: 1229224-94-5) or (R)-N-(1-(Naphthalen-1-yl)ethyl)-3-(3-(trifluoromethyl) phenyl)propan-1-amine N-oxide is an amine adulteration compound of Cinacalcet. The cinacalcet acts on the calcium-sensing receptor to elevate its sensitivity to calcium and therefore lowers the parathyroid hormone (PTH) secretion. Cinacalcet impedes circulating PTH levels by raising the sensitivity of the CaR to extracellular calcium. |
| References | Shah, Mansi, et al. “Capillary Electrophoresis Methods for Impurity Profiling of Drugs: A Review of the Past Decade.” Journal of Pharmaceutical Analysis, July 2021, https://doi.org/10.1016/j.jpha.2021.06.009. Lindberg, Jill S., et al. “Cinacalcet HCl, an Oral Calcimimetic Agent for the Treatment of Secondary Hyperparathyroidism in Hemodialysis and Peritoneal Dialysis: A Randomized, Double-Blind, Multicenter Study.” Journal of the American Society of Nephrology, vol. 16, no. 3, Feb. 2005, pp. 800 |
