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Cinnarizine EP Impurity B

Cinnarizine EP Impurity B

Catalogue No.: VL195003
CAS No.: 750512-44-8

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Name: Cinnarizine EP Impurity B
Catalogue No. VL195003
CAS No. 750512-44-8
Molecular Formula C26H28N2
Molecular Weight 368.51
Status In-stock
IUPAC Name 1-(Diphenylmethyl)-4-[(2Z)-3-phenyl-2-propen-1-yl]piperazine;
Synonyms cis-Cinnarizin
Appearance White solid
Description Cinnarizine EP Impurity B (CAS No: 750512-44-8) or 1-(Diphenylmethyl)-4-[(2Z)-3-phenyl-2-propen-1-yl]piperazine is a Z-isomer of Cinnarizine. Cinnarizine is a non-competitive antagonist of histamine, noradrenaline, nicotine, and angiotensin and has direct actions, all involve antagonism of the stimulated influx of extracellular calcium (Ca(Ca++) ions.
References Shakhmaev, R. N., et al. “Iron-Catalyzed Synthesis of Cinnarizine.” Russian Journal of Organic Chemistry, vol. 51, no. 1, Jan. 2015, pp. 95–97, https://doi.org/10.1134/s1070428015010169. Towse, G. “Cinnarizine—a Labyrinthine Sedative.” The Journal of Laryngology & Otology, vol. 94, no. 9, Sept. 1980, pp. 1009–15, https://doi.org/10.1017/s0022215100089787.

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