| Name: | Clarithromycin EP Impurity F |
| Catalogue No. | VL740004 |
| CAS No. | 128940-83-0 |
| Molecular Formula | C39H71NO13 |
| Molecular Weight | 761.98 |
| Status | In-stock |
| IUPAC Name | 6,12-Di-O-methylerythromycin A |
| Synonyms | 12-O-Methyl Clarithromycin / Clarithromycin Impurity F |
| Appearance | Off White powder |
| Description | Clarithromycin EP Impurity F (CAS No: 128940-83-0) or 12-O-Methyl Clarithromycin is a chemical modification of Erythromycin. Erythromycin has a similar effect as that of gastrointestinal polypeptide motilin on gastrointestinal motility. It works by binding to motilin receptors and acts as a motilin agonist. Erythromycin has clinical application in patients with disturbed gastroduodenal motility like in diabetic gastroparesis. |
| References | MORIMOTO, SHIGEO, et al. “Chemical Modification of Erythromycins. VI. Structure and Antibacterial Activity of Acid Degradation Products of 6-O-Methylerythromycins A.” The Journal of Antibiotics, vol. 43, no. 5, 1990, pp. 570–73, https://doi.org/10.7164/antibiotics.43.570. Janssens, J., et al. “Improvement of Gastric Emptying in Diabetic Gastroparesis by Erythromycin.” New England Journal of Medicine, vol. 322, no. 15, Apr. 1990, pp. 1028–31, https://doi.org/10.1056/nejm199004123221502. |
