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Clarithromycin EP Impurity F

Clarithromycin EP Impurity F

Catalogue No.: VL740004
CAS No.: 128940-83-0

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Name: Clarithromycin EP Impurity F
Catalogue No. VL740004
CAS No. 128940-83-0
Molecular Formula C39H71NO13
Molecular Weight 761.98
Status In-stock
IUPAC Name 6,12-Di-O-methylerythromycin A
Synonyms 12-O-Methyl Clarithromycin / Clarithromycin Impurity F
Appearance Off White powder
Description Clarithromycin EP Impurity F (CAS No: 128940-83-0) or 12-O-Methyl Clarithromycin is a chemical modification of Erythromycin. Erythromycin has a similar effect as that of gastrointestinal polypeptide motilin on gastrointestinal motility. It works by binding to motilin receptors and acts as a motilin agonist. Erythromycin has clinical application in patients with disturbed gastroduodenal motility like in diabetic gastroparesis.
References MORIMOTO, SHIGEO, et al. “Chemical Modification of Erythromycins. VI. Structure and Antibacterial Activity of Acid Degradation Products of 6-O-Methylerythromycins A.” The Journal of Antibiotics, vol. 43, no. 5, 1990, pp. 570–73, https://doi.org/10.7164/antibiotics.43.570. ‌Janssens, J., et al. “Improvement of Gastric Emptying in Diabetic Gastroparesis by Erythromycin.” New England Journal of Medicine, vol. 322, no. 15, Apr. 1990, pp. 1028–31, https://doi.org/10.1056/nejm199004123221502.

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