| Name: | Clarithromycin EP Impurity O |
| Catalogue No. | VL740015 |
| CAS No. | 127252-80-6 |
| Molecular Formula | C39H72N2O13 |
| Molecular Weight | 776.99 |
| Status | In-stock |
| IUPAC Name | 6-O-Methylerythromycin A (Z)-9-(O-methyloxime) |
| Synonyms | Clarithromycin Impurity O |
| Appearance | White solid |
| Description | Clarithromycin EP Impurity O (CAS No: 127252-80-6) or 6-O-Methylerythromycin A (Z)-9-(O-methyloxime) is a chemical modification of erythromycin. Erythromycin is a macrolide that functions by blocking the translocation reaction at the time of protein synthesis. Erythromycin, except under alkaline conditions, is inactive against the Enterobacteriaceae and Pseudomonas aeruginosa. |
| References | WATANABE, YOSHIAKI, et al. “Chemical Modification of Erythromycins. IX. Selective Methylation at the C-6 Hydroxyl Group of Erythromycin a Oxime Derivatives and Preparation of Clarithromycin.” The Journal of Antibiotics, vol. 46, no. 4, 1993, pp. 647–60, https://doi.org/10.7164/antibiotics.46.647. WASHINGTON, JOHN A., and WALTER R. WILSON. “Erythromycin: A Microbial and Clinical Perspective after 30 Years of Clinical Use (First of Two Parts).” Mayo Clinic Proceedings, vol. 60, no. 3, Mar. 1985, p |
