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Clobetasol Propionate EP Impurity C

Clobetasol Propionate EP Impurity C

Catalogue No.: VL1950004
CAS No.: 25122-52-5

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Name: Clobetasol Propionate EP Impurity C
Catalogue No. VL1950004
CAS No. 25122-52-5
Molecular Formula C₂₅H₃₂ClFO₅
Molecular Weight 466.97
Status In-stock
IUPAC Name 21-Chloro-9-fluoro-11β-hydroxy-16α-methyl-3,20-dioxopregna-1,4-dien-17-yl propanoate
Description Clobetasol Propionate EP Impurity C (CAS No: 25122-52-5) or 21-Chloro-9-fluoro-11β-hydroxy-16α-methyl-3,20-dioxopregna-1,4-dien-17-yl propanoate is an impurity of Clobetasol Propionate, an anti-inflammatory agent which is also a topical corticosteroid. In psoriasis, it has shown significantly higher potency than class-II steroids and as or more potent than the only marketed class-I steroid.
References SUGAI, SABURO, et al. “A New Efficient Method for Conversion of Corticosteroid 17.ALPHA.,21-Cyclic Ortho Esters to 17.ALPHA.-Acyloxy-21-Chloro-21-Deoxy Derivatives.” Chemical and Pharmaceutical Bulletin, vol. 31, no. 1, 1983, pp. 12–19, https://doi.org/10.1248/cpb.31.12. ‌Olsen, Elise A., and Roger C. Cornell. “Topical Clobetasol-17-Propionate: Review of Its Clinical Efficacy and Safety.” Journal of the American Academy of Dermatology, vol. 15, no. 2, Aug. 1986, pp. 246–55, https://doi.org/10.1

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