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Clomipramine EP Impurity E

Clomipramine EP Impurity E

Catalogue No.: VL2540004
CAS No.: N/A

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Name: Clomipramine EP Impurity E
Catalogue No. VL2540004
Molecular Formula C14H13N
Molecular Weight 195.27
Status In-stock
IUPAC Name 10,11-Dihydro-5H-dibenzo[b,f]azepine
Appearance Off White Powder
Description Clomipramine EP Impurity E or 10,11-Dihydro-5H-dibenzo[b,f]azepine increases cerebral blood flow (CBF), attenuates cognitive impairment, and improves hippocampal atrophy. It also increases the level of histone acetylation (H3K14 or H4K5) and is a potential HDAC inhibitor for the treatment of vascular cognitive impairment.
References Kaur, Navdeep, et al. “Protective Effects of 10,11-Dihydro-5H-Dibenzo[B,F]Azepine Hydroxamates on Vascular Cognitive Impairment.” European Journal of Medicinal Chemistry, vol. 187, Feb. 2020, p. 111915, https://doi.org/10.1016/j.ejmech.2019.111915.

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