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Clotrimazole EP Impurity A

Clotrimazole EP Impurity A

Catalogue No.: VL164001
CAS No.: 66774-02-5

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Name: Clotrimazole EP Impurity A
Catalogue No. VL164001
CAS No. 66774-02-5
Molecular Formula C19H15ClO
Molecular Weight 294.77
Status In-stock
IUPAC Name (2-chlorophenyl)diphenylmethanol
Synonyms Clotrimazole Related Compound A
Appearance White solid
Description Clotrimazole EP Impurity A (CAS No.: 66774-02-5) or Clotrimazole Related Compound A is a degradation product of the compound Clotrimazole. Clotrimazole (CLT) is an antimycotic drug that has been shown to inhibit the mobility of Ca2+ and K+ across the plasma membrane. Clotrimazole blocks the rate of cell proliferation of normal and cancer cell lines in a reversible and dose-dependent manner in vitro.
References HAJKOVA, R., et al. “Development and Validation of HPLC Method for Determination of Clotrimazole and Its Two Degradation Products in Spray Formulation.” Talanta, vol. 73, no. 3, Sept. 2007, pp. 483–89, https://doi.org/10.1016/j.talanta.2007.04.023. ‌Benzaquen, Laura R., et al. “Clotrimazole Inhibits Cell Proliferation in Vitro and in Vivo.” Nature Medicine, vol. 1, no. 6, June 1995, pp. 534–40, https://doi.org/10.1038/nm0695-534.

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