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Colchicine EP Impurity B

Colchicine EP Impurity B

Catalogue No.: VE007041
CAS No.: N/A

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Name: Colchicine EP Impurity B
Catalogue No. VE007041
Molecular Formula C22H25NO6
Molecular Weight 399.44 g/mol
Status In-Stock
IUPAC Name (S)-N-(1,2,3,10-tetramethoxy-9-oxo-5,6,7,9-tetrahydrobenzo[a]heptalen-7-yl)acetamide
Description Colchicine EP Impurity B or (S)-N-(1,2,3,10-tetramethoxy-9-oxo-5,6,7,9-tetrahydrobenzo[a]heptalen-7-yl)acetamide is a derivative of the compound Colchicine. Colchicine is evaluated mainly in the treatment of gout but is also useful in some other inflammatory diseases like familial Mediterranean fever (FMF). It shows its activity by working on tubulin, intestinal and hepatic CYP3A4, and P-glycoprotein.
References Bartusik, Dorota, et al. “Derivatives of Thiocolchicine and Its Applications to CEM Cells Treatment Using 19F Magnetic Resonance Ex Vivo.” Bioorganic Chemistry, vol. 38, no. 1, Feb. 2010, pp. 1–6, https://doi.org/10.1016/j.bioorg.2009.10.002. ‌Niel, Elisabeth, and Jean-Michel Scherrmann. “Colchicine Today.” Joint Bone Spine, vol. 73, no. 6, Dec. 2006, pp. 672–78, https://doi.org/10.1016/j.jbspin.2006.03.006.

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