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Colchicine EP Impurity E

Colchicine EP Impurity E

Catalogue No.: VL3080005
CAS No.: 7336-33-6

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Name: Colchicine EP Impurity E
Catalogue No. VL3080005
CAS No. 7336-33-6
Molecular Formula C21H23NO6
Molecular Weight 385.41
Status In-stock
IUPAC Name N-[(7S)-5,6,7,9-Tetrahydro-3-hydroxy-1,2,10-trimethoxy-9-oxobenzo[a]heptalen-7-yl]-acetamide
Synonyms Colchicine BP Impurity E/ 3-O-Demethyl Colchicine
Appearance Yellow Solid
Description Colchicine EP Impurity E (CAS No.: 7336-33-6) or 3-O-Demethyl Colchicine is a 3-O-Glucosyl derivative and biotransformation product of the compound Colchicine. Colchicine is an ancient medicine and is currently evaluated for the treatment of gout and FMF. Colchicine is also known to have a wide range of anti-inflammatory activities.
References Ponzone, Cesare, et al. “Biotransformation of Colchicinoids into Their Corresponding 3-O-Glucosyl Derivatives by Selected Strains of Bacillus Megaterium.” Molecular Biotechnology, vol. 56, no. 7, Feb. 2014, pp. 653–59, https://doi.org/10.1007/s12033-014-9741-5. ‌Slobodnick, Anastasia, et al. “Update on Colchicine, 2017.” Rheumatology, vol. 57, no. suppl_1, Dec. 2017, pp. i4–11, https://doi.org/10.1093/rheumatology/kex453.

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