| Name: | Colchicine EP Impurity E |
| Catalogue No. | VL3080005 |
| CAS No. | 7336-33-6 |
| Molecular Formula | C21H23NO6 |
| Molecular Weight | 385.41 |
| Status | In-stock |
| IUPAC Name | N-[(7S)-5,6,7,9-Tetrahydro-3-hydroxy-1,2,10-trimethoxy-9-oxobenzo[a]heptalen-7-yl]-acetamide |
| Synonyms | Colchicine BP Impurity E/ 3-O-Demethyl Colchicine |
| Appearance | Yellow Solid |
| Description | Colchicine EP Impurity E (CAS No.: 7336-33-6) or 3-O-Demethyl Colchicine is a 3-O-Glucosyl derivative and biotransformation product of the compound Colchicine. Colchicine is an ancient medicine and is currently evaluated for the treatment of gout and FMF. Colchicine is also known to have a wide range of anti-inflammatory activities. |
| References | Ponzone, Cesare, et al. “Biotransformation of Colchicinoids into Their Corresponding 3-O-Glucosyl Derivatives by Selected Strains of Bacillus Megaterium.” Molecular Biotechnology, vol. 56, no. 7, Feb. 2014, pp. 653–59, https://doi.org/10.1007/s12033-014-9741-5. Slobodnick, Anastasia, et al. “Update on Colchicine, 2017.” Rheumatology, vol. 57, no. suppl_1, Dec. 2017, pp. i4–11, https://doi.org/10.1093/rheumatology/kex453. |
