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Cyclosporine Impurity C

Cyclosporine Impurity C

Catalogue No.: VL1050009
CAS No.: 59787-61-0

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Name: Cyclosporine Impurity C
Catalogue No. VL1050009
CAS No. 59787-61-0
Molecular Formula C₆₂H₁₁₁N₁₁O₁₃
Molecular Weight 1218.64
Status In-stock
IUPAC Name Thr2-cyclosporine;
Description Cyclosporine Impurity C (CAS No.: 59787-61-0) is an analogue and a biotransformation product of Cyclosporine. Cyclosporine is proved to have immunosuppressive and nephrotoxic activity and it acts by blocking the phosphatase activity of calcineurin which is responsible for the regulation of nuclear translocation.
References Jeffery, John R. “Cyclosporine Analogues.” Clinical Biochemistry, vol. 24, no. 1, Feb. 1991, pp. 15–21,https://doi.org/10.1016/0009-9120(91)90105-n.‌Gmur, Dennis J., et al. “High-Performance Liquid Chromatographic Column-Switching Method for Two Cyclosporine Metabolites in Blood.” Journal of Chromatography B: Biomedical Sciences and Applications, vol. 425, Jan. 1988, pp. 343–52,https://doi.org/10.1016/0378-4347(88)80038-0.‌

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