| Name: | Cyclosporine Impurity D |
| Catalogue No. | VL1050005 |
| CAS No. | 63775-96-2 |
| Molecular Formula | C₆₃H111N₁₁O₁₂ |
| Molecular Weight | 1214.62 |
| Status | In-stock |
| IUPAC Name | Cyclo[L-alanyl-D-alanyl-N-methyl-L-leucyl-N-methyl-L-leucyl-N-methyl-L-valyl-(3R,4R,6E)-6,7-didehydro-3-hydroxy-N,4-dimethyl-L-2-aminooctanoyl-L-valyl-N-methylglycyl-N-methyl-L-leucyl-L-valyl-N-methyl-L-leucyl]; |
| Description | Cyclosporine Impurity D (CAS No.: 63775-96-2) is a weak immunosuppressant and is also an immunologically inactive compound that is a potent blocker of phorbol ester TPA-induced biological effects in mouse skin and of Calcium calmodulin-dependent EF-2 phosphorylation. |
| References | Gschwendt, M., et al. “The Weak Immunosuppressant Cyclosporine D as Well as the Immunologically Inactive Cyclosporine H Are Potent Inhibitors in Vivo of Phorbol Ester TPA-Induced Biological Effects in Mouse Skin and of Ca2+Calmodulin Dependent EF-2 Phosphorylation in Vitro.” Biochemical and Biophysical Research Communications, vol. 150, no. 2, Jan. 1988, pp. 545–51,https://doi.org/10.1016/0006-291x(88)90428-7. |
