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Cyclosporine Impurity D

Cyclosporine Impurity D

Catalogue No.: VL1050005
CAS No.: 63775-96-2

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Name: Cyclosporine Impurity D
Catalogue No. VL1050005
CAS No. 63775-96-2
Molecular Formula C₆₃H111N₁₁O₁₂
Molecular Weight 1214.62
Status In-stock
IUPAC Name Cyclo[L-alanyl-D-alanyl-N-methyl-L-leucyl-N-methyl-L-leucyl-N-methyl-L-valyl-(3R,4R,6E)-6,7-didehydro-3-hydroxy-N,4-dimethyl-L-2-aminooctanoyl-L-valyl-N-methylglycyl-N-methyl-L-leucyl-L-valyl-N-methyl-L-leucyl];
Description Cyclosporine Impurity D (CAS No.: 63775-96-2) is a weak immunosuppressant and is also an immunologically inactive compound that is a potent blocker of phorbol ester TPA-induced biological effects in mouse skin and of Calcium calmodulin-dependent EF-2 phosphorylation.
References Gschwendt, M., et al. “The Weak Immunosuppressant Cyclosporine D as Well as the Immunologically Inactive Cyclosporine H Are Potent Inhibitors in Vivo of Phorbol Ester TPA-Induced Biological Effects in Mouse Skin and of Ca2+Calmodulin Dependent EF-2 Phosphorylation in Vitro.” Biochemical and Biophysical Research Communications, vol. 150, no. 2, Jan. 1988, pp. 545–51,https://doi.org/10.1016/0006-291x(88)90428-7.‌

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