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Dapagliflozin Bromomethanone

Dapagliflozin Bromomethanone

Catalogue No.: VE006597
CAS No.: 461432-22-4

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Name: Dapagliflozin Bromomethanone
Catalogue No. VE006597
CAS No. 461432-22-4
Molecular Formula C15H12BrClO2
Molecular Weight 339.61
Status In-stock
IUPAC Name (5-bromo-2-chlorophenyl)(4-ethoxyphenyl)methanone
Synonyms Dapagliflozin Impurity 6
Description Dapagliflozin Bromomethanone (CAS No.: 461432-22-4) or Dapagliflozin Impurity 6 is an inter­mediate in the synthesis of Dapagliflozin which shows a strong biological activity. Dapagliflozin is an orally ingested sodium-glucose co-transporter-2 (SGLT2) inhibitor evaluated in the management of patients having type 2 diabetes. Dapagliflozin lowers renal glucose reabsorption by blocking the transporter protein SGLT2.
References Shao, Hua, et al. “(5-Bromo-2-Chlorophenyl)(4-Ethoxyphenyl)Methanone.” Acta Crystallographica Section E Structure Reports Online, vol. 65, no. 12, Nov. 2009, pp. o3071–71,https://doi.org/10.1107/s1600536809047151.‌Plosker, Greg L. “Dapagliflozin: A Review of Its Use in Patients with Type 2 Diabetes.” Drugs, vol. 74, no. 18, Nov. 2014, pp. 2191–209,https://doi.org/10.1007/s40265-014-0324-3.‌

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