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Dapagliflozin Hydroxy impurity

Dapagliflozin Hydroxy impurity

Catalogue No.: VL1650007
CAS No.: 1204222-85-4

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Name: Dapagliflozin Hydroxy impurity
Catalogue No. VL1650007
CAS No. 1204222-85-4
Molecular Formula C21H25ClO7
Molecular Weight 424.87
Status In-stock
IUPAC Name (2S,3R,4R,5S,6R)-2-(4-chloro-3-((4-ethoxyphenyl)(hydroxy)methyl)phenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol
Appearance White Powder
Description Dapagliflozin Hydroxy impurity (CAS No.: 1204222-85-4) or (2S,3R,4R,5S,6R)-2-(4-chloro-3-((4-ethoxyphenyl)(hydroxy)methyl)phenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol is a synthetic metabolite of Dapagliflozin which is a selective sodium-glucose cotransporter-2 blocker which diminishes renal glucose reabsorption in an insulin-independent manner and helps in the correction of hyperglycemia and prevention of glucotoxicity.
References KARUMANCHI, KISHORE, et al. “Synthesis of Metabolites of Dapagliflozin: An SGLT2 Inhibitor.” Journal of Chemical Sciences, vol. 132, no. 1, Feb. 2020,https://doi.org/10.1007/s12039-020-1747-x.‌Bailey, Clifford J., et al. “Effect of Dapagliflozin in Patients with Type 2 Diabetes Who Have Inadequate Glycaemic Control with Metformin: A Randomised, Double-Blind, Placebo-Controlled Trial.” The Lancet, vol. 375, no. 9733, June 2010, pp. 2223–33,https://doi.org/10.1016/s0140-6736(10)60407-2.‌

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