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Dapagliflozin Methoxy Impurity

Dapagliflozin Methoxy Impurity

Catalogue No.: VL1650002
CAS No.: 714269-57-5

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Name: Dapagliflozin Methoxy Impurity
Catalogue No. VL1650002
CAS No. 714269-57-5
Molecular Formula C22H27ClO7
Molecular Weight 438.9
Status In-stock
IUPAC Name (2S,3R,5S,6R)-2-(4-chloro-3-(4-ethoxybenzyl)phenyl)-6-(hydroxymethyl)-2-methoxytetrahydro-2H-pyran-3,4,5-triol
Appearance white solid
Description Dapagliflozin Methoxy Impurity (CAS No.: 714269-57-5) or (2S,3R,5S,6R)-2-(4-chloro-3-(4-ethoxybenzyl)phenyl)-6-(hydroxymethyl)-2-methoxytetrahydro-2H-pyran-3,4,5-triol is a methoxy group impurity of Dapagliflozin which is a synthetic SGLT-2 blocker and therefore increases renal glucose excretion which then leads to diminished plasma glucose levels.
References Chen, Yanqing, et al. “Isolation and Characterization of Novel Process-Related Impurities in Empagliflozin.” Journal of Pharmaceutical and Biomedical Analysis, vol. 198, May 2021, p. 114001,https://doi.org/10.1016/j.jpba.2021.114001.‌Anderson, Sarah L. “Dapagliflozin Efficacy and Safety: A Perspective Review.” Therapeutic Advances in Drug Safety, vol. 5, no. 6, Sept. 2014, pp. 242–54,https://doi.org/10.1177/2042098614551938.‌

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