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Dapagliflozin Open Ring Impurity

Dapagliflozin Open Ring Impurity

Catalogue No.: VL1650016
CAS No.: 2100872-88-4

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Name: Dapagliflozin Open Ring Impurity
Catalogue No. VL1650016
CAS No. 2100872-88-4
Molecular Formula C₂₁H₂₇ClO₇
Molecular Weight 426.89
Status In-stock
IUPAC Name 1-C-[4-Chloro-3-[(4-ethoxyphenyl)methyl]phenyl]-D-glucitol
Description Dapagliflozin Open Ring Impurity (CAS No.: 2100872-88-4) or 1-C-[4-Chloro-3-[(4-ethoxyphenyl)methyl]phenyl]-D-glucitol is a metabolite of Dapagliflozin which is a highly effective and selective sodium-glucose cotransporter-2 blocker used around the globe for the treatment of type 2 diabetes (T2D). It possesses antihyperglycaemic, cardioprotective and somewhat renoprotective properties.
References “Formulation of Amorphous Ternary Solid Dispersions of Dapagliflozin Using PEG 6000 and Poloxamer 188: Solid-State Characterization, Ex Vivo Study, and Molecular Simulation Assessment.” Drug Development and Industrial Pharmacy, 2020,www.tandfonline.com/doi/abs/10.1080/03639045.2020.1802482.‌Dhillon, Sohita. “Dapagliflozin: A Review in Type 2 Diabetes.” Drugs, vol. 79, no. 10, June 2019, pp. 1135–46,https://doi.org/10.1007/s40265-019-01148-3.‌

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