
Name: | Dapagliflozin Open Ring Impurity |
Catalogue No. | VL1650016 |
CAS No. | 2100872-88-4 |
Molecular Formula | C₂₁H₂₇ClO₇ |
Molecular Weight | 426.89 |
Status | In-stock |
IUPAC Name | 1-C-[4-Chloro-3-[(4-ethoxyphenyl)methyl]phenyl]-D-glucitol |
Description | Dapagliflozin Open Ring Impurity (CAS No.: 2100872-88-4) or 1-C-[4-Chloro-3-[(4-ethoxyphenyl)methyl]phenyl]-D-glucitol is a metabolite of Dapagliflozin which is a highly effective and selective sodium-glucose cotransporter-2 blocker used around the globe for the treatment of type 2 diabetes (T2D). It possesses antihyperglycaemic, cardioprotective and somewhat renoprotective properties. |
References | “Formulation of Amorphous Ternary Solid Dispersions of Dapagliflozin Using PEG 6000 and Poloxamer 188: Solid-State Characterization, Ex Vivo Study, and Molecular Simulation Assessment.” Drug Development and Industrial Pharmacy, 2020,www.tandfonline.com/doi/abs/10.1080/03639045.2020.1802482.Dhillon, Sohita. “Dapagliflozin: A Review in Type 2 Diabetes.” Drugs, vol. 79, no. 10, June 2019, pp. 1135–46,https://doi.org/10.1007/s40265-019-01148-3. |