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Desloratadine EP Impurity B

Desloratadine EP Impurity B

Catalogue No.: VL41005
CAS No.: 183198-49-4 (base) ; 432543-89-0 (HCl)

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Name: Desloratadine EP Impurity B
Catalogue No. VL41005
CAS No. 183198-49-4 (base) ; 432543-89-0 (HCl)
Molecular Formula C₁₉H₁₉ClN₂
Molecular Weight 310.82
Status In-stock
IUPAC Name 8-Chloro-6,11-dihydro-11-(1,2,3,6-tetrahydro-4-pyridinyl)-5H-benzo[5,6]cyclohepta[1,2-b]pyridine
Description Desloratadine EP Impurity B (CAS No.: 183198-49-4) or 8-Chloro-6,11-dihydro-11-(1,2,3,6-tetrahydro-4-pyridinyl)-5H-benzo[5,6]cyclohepta[1,2-b]pyridine is an impurity of Desloratadine which is a biologically active metabolite of the second-generation antihistamine loratadine. Desloratadine is a highly selective peripheral H1 receptor inhibitor that is extensively more efficient than loratadine.
References ‌El-Enany, Nahed, et al. “Spectrophotometric, Spectrofluorometric and HPLC Determination of Desloratadine in Dosage Forms and Human Plasma.” Chemical and Pharmaceutical Bulletin, vol. 55, no. 12, 2007, pp. 1662–70,https://doi.org/10.1248/cpb.55.1662.‌“Pharmacology and Clinical Efficacy of Desloratadine as an Anti-Allergic and Anti-Inflammatory Drug.” Expert Opinion on Investigational Drugs, 2021,www.tandfonline.com/doi/abs/10.1517/13543784.10.3.547.‌

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