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Desloratadine N Oxide

Desloratadine N Oxide

Catalogue No.: VL41002
CAS No.: 169253-26-3

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Name: Desloratadine N Oxide
Catalogue No. VL41002
CAS No. 169253-26-3
Molecular Formula C₁₉H₁₉ClN₂O
Molecular Weight 326.82
Status In-stock
IUPAC Name 8-Chloro-6,11-dihydro-11-(4-piperidinylidene)-5H-benzo[5,6]cyclohepta[1,2- b]pyridine 1-Oxide
Synonyms N-Oxide Derivative of Desloratidine
Description Desloratadine N Oxide (CAS No.: 169253-26-3) or 8-Chloro-6,11-dihydro-11-(4-piperidinylidene)-5H-benzo[5,6]cyclohepta[1,2- b]pyridine 1-Oxide is an N-Oxide metabolite of Desloratadine which is a potent antihistaminic compound and increasing desloratadine up to 4-fold betters the chronic urticaria symptoms without altering the safety in patients with difficult-to-treat chronic urticaria.
References Zheng, Jinjian, and Abu M. Rustum. “Rapid Separation of Desloratadine and Related Compounds in Solid Pharmaceutical Formulation Using Gradient Ion-Pair Chromatography.” Journal of Pharmaceutical and Biomedical Analysis, vol. 51, no. 1, Jan. 2010, pp. 146–52,https://doi.org/10.1016/j.jpba.2009.08.024.‌Staevska, Maria, et al. “The Effectiveness of Levocetirizine and Desloratadine in up to 4 Times Conventional Doses in Difficult-To-Treat Urticaria.” Journal of Allergy and Clinical Immunology, vol.

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