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Desloratadine Related Compound F

Desloratadine Related Compound F

Catalogue No.: VL41001
CAS No.: 117810-61-4

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Name: Desloratadine Related Compound F
Catalogue No. VL41001
CAS No. 117810-61-4
Molecular Formula C20H19ClN2O
Molecular Weight 338.83
Status In-stock
IUPAC Name 4-(8-Chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-1-piperidinecarboxaldehyde
Synonyms Desloratadine N-Formyl / Loratadine N-Formyl
Appearance Off white powder
Description Desloratadine Related Compound F (CAS No.: 117810-61-4) or 4-(8-Chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-1-piperidinecarboxaldehyde is an N-formyl derivative of Desloratadine which is an inhibitor of the human histamine H1 receptor. Desloratadine is attached to membranes expressing the recombinant human histamine H1 receptor and has high potency and 24-h duration of action.
References Zheng, Jinjian, and Abu M. Rustum. “Rapid Separation of Desloratadine and Related Compounds in Solid Pharmaceutical Formulation Using Gradient Ion-Pair Chromatography.” Journal of Pharmaceutical and Biomedical Analysis, vol. 51, no. 1, Jan. 2010, pp. 146–52,https://doi.org/10.1016/j.jpba.2009.08.024.‌Anthes, John C., et al. “Biochemical Characterization of Desloratadine, a Potent Antagonist of the Human Histamine H1 Receptor.” European Journal of Pharmacology, vol. 449, no. 3, Aug. 2002, pp. 229

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