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Dexamethasone 17-Ketone

Dexamethasone 17-Ketone

Catalogue No.: VE005887
CAS No.: N/A

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Name: Dexamethasone 17-Ketone
Catalogue No. VE005887
CAS No. N/A
Molecular Formula C20H25FO3
Molecular Weight 332.42
Status In-stock
IUPAC Name (8S,9R,10S,11S,13S,14S)-9-fluoro-11-hydroxy-10,13,16-trimethyl-7,8,9,10,11,12,13,14,15,16-decahydro-
Appearance White Powder
Description Dexamethasone 17-Ketone or (8S,9R,10S,11S,13S,14S)-9-fluoro-11-hydroxy-10,13,16-trimethyl-7,8,9,10,11,12,13,14,15,16-decahydro- is a degradation product of Dexamethasone which is the first compound to extensively better the survival in an RCT in COVID-19 patients. It is also an extensively used drug that is widely evaluated and cost-effective.
References Kane, Michael P., and Kiyoshi Tsuji. “Radiolytic Degradation Scheme for 60Co-Irradiated Corticosteroids.” Journal of Pharmaceutical Sciences, vol. 72, no. 1, Jan. 1983, pp. 30–35,https://doi.org/10.1002/jps.2600720108.‌Lammers, Twan, et al. “Dexamethasone Nanomedicines for COVID-19.” Nature Nanotechnology, vol. 15, no. 8, Aug. 2020, pp. 622–24,https://doi.org/10.1038/s41565-020-0752-z.‌

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