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Dihydroxycyclophosphamide

Dihydroxycyclophosphamide

Catalogue No.: VE006893
CAS No.: 90632-33-0

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Name: Dihydroxycyclophosphamide
Catalogue No. VE006893
CAS No. 90632-33-0
Molecular Formula C₇H₁₇N₂O₄P
Molecular Weight 224.19
Status In0stock
IUPAC Name 2-(Bis(2-hydroxyethyl)amino)-1,3,2-oxazaphosphinane 2-Oxide
Synonyms Didechlorodihydroxycyclophosphamide
Description Dihydroxycyclophosphamide (CAS No.: 90632-33-0) or 2-(Bis(2-hydroxyethyl)amino)-1,3,2-oxazaphosphinane 2-Oxide is a metabolite of Cyclophosphamide. Cyclophosphamide is evaluated in chemotherapy and is a part of the standard treatment of Cancer. It is activated to alkylating metabolites by cytochrome P-450.
References "Gurtoo, H. L., et al. “Effects of the Induction of Hepatic Microsomal Metabolism on the Toxicity of Cyclophosphamide.” British Journal of Cancer, vol. 51, no. 1, Jan. 1985, pp. 67–75,https://doi.org/10.1038/bjc.1985.10.‌Clarke, Lynn, and David J. Waxman. “Oxidative Metabolism of Cyclophosphamide: Identification of the Hepatic Monooxygenase Catalysts of Drug Activation.” Cancer Research, vol. 49, no. 9, American Association for Cancer Research, May 1989, pp. 2344–50, cancerres.aacrjournals.org/c

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