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Diltiazem EP Impurity E

Diltiazem EP Impurity E

Catalogue No.: VL1080003
CAS No.: 42399-49-5

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Name: Diltiazem EP Impurity E
Catalogue No. VL1080003
CAS No. 42399-49-5
Molecular Formula C₁₆H₁₅NO₃S
Molecular Weight 301.36
Status In-stock
IUPAC Name 2S,3S)-3-Hydroxy-2-(4-methoxyphenyl)-2,3-dihydro-1,5- benzothiazepin-4(5H)-one
Description Diltiazem EP Impurity E (CAS No.: 42399-49-5) or 2S,3S)-3-Hydroxy-2-(4-methoxyphenyl)-2,3-dihydro-1,5- benzothiazepin-4(5H)-one is a reaction intermediate of Diltiazem which is a calcium antagonist. Diltiazem blocks the sluggish inward calcium current and thus prolongs the effective and functional refractory time of the atrioventricular node and intranodal (A-H) conduction.
References Ishii, K., et al. “Assay of Four Stereoisomers of Desacetyl Diltiazem Hydrochloride. Application Toin Vitro Chiral Inversion Studies.” Chromatographia, vol. 43, no. 7-8, Oct. 1996, pp. 413–18,https://doi.org/10.1007/bf02271021.‌Buckley, Micaela M. -T ., et al. “Diltiazem.” Drugs, vol. 39, no. 5, May 1990, pp. 757–806,https://doi.org/10.2165/00003495-199039050-00009.‌

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