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Diltiazem Sulfoxide

Diltiazem Sulfoxide

Catalogue No.: VL1080008
CAS No.: 370094-12-5

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Name: Diltiazem Sulfoxide
Catalogue No. VL1080008
CAS No. 370094-12-5
Molecular Formula C₂₂H₂₆N₂O₅S
Molecular Weight 430.52
Status In-stock
IUPAC Name (2S,3S)-5-(2-(Dimethylamino)ethyl)-2-(4-methoxyphenyl)-1-oxido-4-oxo-2,3,4,5-tetrahydrobenzo[b][1,4]thiazepin-3-yl Acetate
Description Diltiazem Sulfoxide (CAS No.: 370094-12-5) or (2S,3S)-5-(2-(Dimethylamino)ethyl)-2-(4-methoxyphenyl)-1-oxido-4-oxo-2,3,4,5-tetrahydrobenzo[b][1,4]thiazepin-3-yl Acetate is a major degradation product of Diltiazem which is a calcium antagonist efficacious in the treatment of stable, variant and unstable angina pectoris and mild to moderate systemic hypertension. It is also efficacious in stopping supraventricular tachycardia and in commanding the ventricular response to atrial fibrillation.
References Chatpalliwar, Vivekanand A., et al. “Validated Gradient Stability Indicating HPLC Method for Determining Diltiazem Hydrochloride and Related Substances in Bulk Drug and Novel Tablet Formulation.” Journal of Pharmaceutical Analysis, vol. 2, no. 3, June 2012, pp. 226–37,https://doi.org/10.1016/j.jpha.2012.01.003.‌Buckley, Micaela M. -T ., et al. “Diltiazem.” Drugs, vol. 39, no. 5, May 1990, pp. 757–806,https://doi.org/10.2165/00003495-199039050-00009.‌

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