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Doxycycline EP Impurity B (HCl salt)

Doxycycline EP Impurity B (HCl salt)

Catalogue No.: VL159005
CAS No.: 3963-95-9

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Name: Doxycycline EP Impurity B (HCl salt)
Catalogue No. VL159005
CAS No. 3963-95-9
Molecular Formula C22H23ClN2O8
Molecular Weight 478.88
Status In-stock
IUPAC Name (4S,4aR,5S,5aR,12aS)-4-(Dimethylamino)-3,5,10,12,12a-pentahydroxy-6-methylene-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide HCl
Synonyms Methacycline Impurity
Description Doxycycline EP Impurity B (HCl salt) or Methacycline Impurity (CAS No.3963-95-9) or (4S,4aR,5S,5aR,12aS)-4-(Dimethylamino)-3,5,10,12,12a-pentahydroxy-6-methylene-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide HCl. It is from second generation Tetracycline class of antibiotics. It ia a synthetic derivative of oxytetracyclinre. Its absorption decreases with the antacids.
References "Smith, Kelly, and James J. Leyden. “Safety of Doxycycline and Minocycline: A Systematic Review.” Clinical Therapeutics, vol. 27, no. 9, Sept. 2005, pp. 1329–42, https://doi.org/10.1016/j.clinthera.2005.09.005. ‌Saivin, S., and G. Houin. “Clinical Pharmacokinetics of Doxycycline and Minocycline.” Clinical Pharmacokinetics, vol. 15, no. 6, Dec. 1988, pp. 355–66, https://doi.org/10.2165/00003088-198815060-00001. ‌"

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