| Name: | Doxycycline EP Impurity B (free base) |
| Catalogue No. | VE006171 |
| CAS No. | 914-00-1 |
| Molecular Formula | C22H22N2O8 |
| Molecular Weight | 442.42 |
| Status | In-stock |
| IUPAC Name | (4S,4aR,5S,5aR,12aS)-4-(Dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,10,12,12a-pentahydroxy-6-methylene-1,11-dioxo-2-naphthacenecarboxamide |
| Synonyms | Methacycline |
| Description | Doxycycline EP Impurity B (free base) or Methacycline (CAS No. 914-00-1) or (4S,4aR,5S,5aR,12aS)-4-(Dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,10,12,12a-pentahydroxy-6-methylene-1,11-dioxo-2-naphthacenecarboxamide. It is from second generation Tetracycline class of antibiotics. It ia a synthetic derivative of oxytetracyclinre. Its absorption decreases with the antacids. |
| References | "Smith, Kelly, and James J. Leyden. “Safety of Doxycycline and Minocycline: A Systematic Review.” Clinical Therapeutics, vol. 27, no. 9, Sept. 2005, pp. 1329–42, https://doi.org/10.1016/j.clinthera.2005.09.005. Saivin, S., and G. Houin. “Clinical Pharmacokinetics of Doxycycline and Minocycline.” Clinical Pharmacokinetics, vol. 15, no. 6, Dec. 1988, pp. 355–66, https://doi.org/10.2165/00003088-198815060-00001. " |
